FACULTY

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Dr Buddhadeb Chattopadhyay

Associate Professor


Faculty Profile

Address Department of Biological & Synthetic Chemistry Center of Biomedical Research (CBMR) SGPGIMS Campus, Raebareli Road Lucknow 226014, Uttar Pradesh India
Building Old Building Room no 219
Lab no: 111 Intercom: 219
Email: buddhadeb.c@cbmr.res.in
Url https://buddhadeb-cbmr.weebly.com/

Research Interest

Transition metal-mediated C–H bond activation/functionalization, Development of new synthetic methodologies, Design and synthesis of new ligands and catalytic systems for organic reactions, Organometallics, especially organo-boron and organo-silicon chemistry.

About

Buddhadeb was born and raised in Insura-Hooghly, West Bengal. He obtained his B.Sc. (2001) in chemistry from the Burdwan University and M.Sc. (2003) in chemistry from Visva-Bharati University. In 2003, he left Visva-Bharati and enrolled in Kalyani University for his Ph.D. in the laboratories of Professor K. C. Majumdar. In 2009, he accepted a postdoctoral research associateship from the University of Illinois at Chicago, USA in the group of Professor Vladimir Gevorgyan.

Spending two years at Chicago, he then moved to the Michigan State University, Michigan, USA for his next postdoctoral research program in the laboratories of Professor Milton R. Smith III. Group (2011-July 2014). In August 2014, he moved to the Centre of Bio-Medical Research (CBMR) Lucknow, India as a DST-Ramanujan Fellow to start his independent research career. In November 2016, he joined as an Assistant Professor and promoted to Associate Professor in November 2019. His research interest includes the catalyst/ligand engineering for the C–H bond activation/functionalization, especially C–H bond borylations of organic molecules and metal-nitrene/carbene chemistry by means of denitrogenative transformations to make high-valued nitrogen heterocycles.

Research

  • Research Interests:

    • Transition metal-mediated C–H bond activation/functionalization via noncovalent interactions
    • Development of new synthetic methodologies and drug discovery
    • Design and synthesis of new ligands and catalytic systems for organic reactions
    • Organometallics, especially organo-boron and organo-silicon chemistry
    • Metal-nitrene/carbene chemistry

Group Members

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Mr. Mirja Md Mahamudul Hassan

M.Sc. (IIT-Kharagpur)  

5th Year Ph.D. Student (UGC-SRF)  

Joined Group: July 2017  

Email: wasim8759@gmail.com

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Mr. Hillol Khatua

M.Sc. (IIT-Kharagpur)  

5th Year Ph.D. Student (UGC-SRF)  

Joined Group: July 2017  

Email: wasim8759@gmail.com

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Mr. Subrata Das

M.Sc. (IIT-Kharagpur)  

5th Year Ph.D. Student (UGC-SRF)  

Joined Group: July 2017  

Email: wasim8759@gmail.com

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Mr. Sayan Dey

M.Sc. (IIT-Kharagpur)  

5th Year Ph.D. Student (UGC-SRF)  

Joined Group: July 2017  

Email: wasim8759@gmail.com

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Mr. Saikat Guria

M.Sc. (IIT-Kharagpur)  

5th Year Ph.D. Student (UGC-SRF)  

Joined Group: July 2017  

Email: wasim8759@gmail.com

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Ms. Sima Patra

M.Sc. (IIT-Kharagpur)  

5th Year Ph.D. Student (UGC-SRF)  

Joined Group: July 2017  

Email: wasim8759@gmail.com

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Ms. Jaitri Das

M.Sc. (IIT-Kharagpur)  

5th Year Ph.D. Student (UGC-SRF)  

Joined Group: July 2017  

Email: wasim8759@gmail.com

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Mr. Anogh Ghosh

M.Sc. (IIT-Kharagpur)  

5th Year Ph.D. Student (UGC-SRF)  

Joined Group: July 2017  

Email: wasim8759@gmail.com

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Mr. Souvik Nandi

M.Sc. (IIT-Kharagpur)  

5th Year Ph.D. Student (UGC-SRF)  

Joined Group: July 2017  

Email: wasim8759@gmail.com

Publications

  1. Transition Metal-Catalyzed Denitrogenative Annulation to Access High-Valued N-Heterocycles. Das, S. K.; Roy, S.; Chattopadhyay, B. Angew. Chem. Int. Ed. 2023, 62, e202210912. [Link]

    Click here for more
  2. Iron-Catalyzed Intermolecular Amination of Benzylic C(sp3)–H Bonds. Khatua, H.; Das, S.; Patra, S.; Das, S. K.; Roy, S.; Chattopadhyay, B. J. Am. Chem. Soc. 2022, 144, 21858–21866.

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  3. Metal-Catalysed C–H Bond Activation and Borylation. Bisht, R.; Haldar, C.; Hassan, M. M. M.; Hoque, E. M.; Chaturvedi, J.; Chattopadhyay, B. Chem. Soc. Rev. 2022, 51, 5042-5100.

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  4. Iridium-Catalyzed Ligand-Controlled Remote para-Selective C–H Activation and Borylation of Twisted Aromatic Amides. Hoque, E. M.; Bisht, R.; Unnikrishnan, A.; Dey, S.; Hassan, M. M. M.; Guria, S.; Rai, R. N.; Sunoj, R. B.; Chattopadhyay, B. Angew. Chem. Int. Ed. 2022, 61, e202203539.

    Click here for more
  5. Road Map for the Construction of High-Valued N-Heterocycles via Denitrogenative Annulation. Roy, S.; Das, S. K.; Khatua, H.; Das, S.; Chattopadhyay, B. Acc. Chem. Res. 2021, 54, 4395–4409.

    Click here for more
  6. Meta Selective C–H Borylation of Sterically Biased and Unbiased Substrates Directed by Electrostatic Interaction. Chaturvedi, J.; Haldar, C.; Bisht, R.; Pandey, G.; Chattopadhyay, B. J. Am. Chem. Soc. 2021, 143, 7604-7611.

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  7. Remarkably Efficient Iridium Catalysts for Directed C(sp2)−H and C(sp3)−H Borylation of Diverse Classes of Substrates. Hoque, E.; Hassan, M. M. M.; Chattopadhyay, B. J. Am. Chem. Soc. 2021, 143, 5022–5037.

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  8. Iron‐Catalyzed Radical Activation Mechanism for Denitrogenative Rearrangement Over C(sp3)–H Amination. Roy, S.; Das, S. K.; Khatua, H.; Das, S.; Singh, K. N.; Chattopadhyay, B. Angew. Chem. Int. Ed. 2021, 60, 8772-8780.

    Click here for more
  9. Dual Reactivity of 1,2,3,4‐Tetrazole: Manganese‐Catalyzed Click Reaction and Denitrogenative Annulation. Hillol Khatua, Sandip Kumar Das, Satyajit Roy, Chattopadhyay, B. Angew. Chem. Int. Ed. 2021, 60, 304-312.

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  10. Iron-Catalyzed Amination of Strong Aliphatic C(sp3)–H Bonds. Sandip Kumar Das, Satyajit Roy, Hillol Khatua, Chattopadhyay, B. J. Am. Chem. Soc. 2020, 142, 16211-16217.

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  11. Iron(II)‐Based Metalloradical Activation: Switch from Traditional Click Chemistry to Denitrogenative Annulation. Roy, S.; Khatua, H.; Das, S. K.; Chattopadhyay, B. Angew. Chem. Int. Ed. 2019, 58, 11439-11443.

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  12. Amide Effect in C–H Activation: Noncovalent Interactions with L‐Shaped Ligand for meta Borylation of Aromatic Amides. Bisht, R.; Hoque, E.; Chattopadhyay, B. Angew. Chem. Int. Ed. 2018, 57, 15762-15766

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  13. Ir-Catalyzed Intramolecular Transannulation/C(sp2)–H Amination of 1,2,3,4-Tetrazoles by Electrocyclization. Das, S. K.; Roy, S.; Khatua, H.; Chattopadhyay, B. J. Am. Chem. Soc. 2018, 140, 8429-8433.

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  14. Cobalt(II)-Based Metalloradical Activation of 2-(Diazomethyl)pyridines for Radical Transannulation and Cyclopropanation. Roy, S.; Das, S. K.; Chattopadhyay, B. Angew. Chem. Int. Ed. 2018, 57, 2238-2243.

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  15. Noncovalent Interactions in Ir-Catalyzed C–H Activation: L-Shaped Ligand for Para-Selective Borylation of Aromatic Esters. Hoque, E.; Bisht, R.; Haldar, C.; Chattopadhyay, B. J. Am. Chem. Soc. 2017, 139, 7745-7748.

    Click here for more
  16. Ir-Catalyzed Ortho Borylation of Phenols Directed by Substrate-Ligand Electrostatic Interactions: A Combined Experimental/in Silico Strategy for Optimizing Weak Interactions. Chattopadhyay, B.; Dannatt, J. E.; Sanctis, I. L. A.-de.; Gore, K. A.; Maleczka, R. E.; Singleton, D. A.; Smith, M. R. J. Am. Chem. Soc. 2017, 139, 7864-7871.

    Click here for more
  17. Formal Ir-Catalyzed Ligand-Enabled Ortho- and Meta-Borylation of Aromatic Aldehydes via in Situ Generated Imines. Bisht, R.; Chattopadhyay, B. J. Am. Chem. Soc. 2016, 138, 84-87.

    Click here for more

Alumni

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Dr. Ranjana Bisht

Current Position: Postdoctoral Associate, University of Manchester, UK
(From May November 2020 to Present)
Advisor: Professor David Procter
Previous Position: Graduate Student (From September 2014 to September 2019), Postdoctoral Research Associate (From October 2019 to November 2020)
Email: ranjanabisht1990@gmail.com

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Dr. Satyajit Roy

Current Position: Postdoctoral Associate, Department of Chemistry, University of Rochester, Rochester, USA
(From May May 2021 to present)
Advisor: Professor Rudi Fasan
Previous Position: Graduate Student (From July 2015 to February 2021)
Email: satyaroy1993@gmail.com

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Dr. Md Emdadul Hoque

Current Position: Postdoctoral Associate, Department of Chemistry, The Scripps Research Institute, USA
(From May October 2021 to present)
Advisor: Professor Jin-Quan Yu
Previous Position: Graduate Student (From January 2016 to February 2021), Postdoctoral Research Associate (From March 2021 to September 2021)
Email: emdadulmd13@gmail.com

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Dr. Sandip Kumar Das

Current Position: Postdoctoral Associate, Department of Chemistry, University of Alberta, Canada
(From May June 2022 to present)
Advisor: Professor Rylan Lundgren
Previous Position: Graduate Student (From July 2016 to December 2021), Postdoctoral Research Associate (From December 2021 to May 2022)
Email: sandip2012.chem@gmail.com

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Dr. Chabush Haldar

Current Position: Postdoctoral Associate, Department of Chemistry & Biochemistry, Baylor University USA
(From May December 2022 to present)
Advisor: Professor Liela Romero
Previous Position: Graduate Student (From November 2015 to January 2022)
Email: chemistchabush@gmail.com

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Dr. Jagriti Chaturvedi

Current Position: Scientist, Aragen Life Sciences, Hyderabad, India
(From May November 2022 to Present)
Advisor: N/A
Previous Position: Graduate Student (From January 2017 to April 2022)
Email: 15jagriti@gmail.com

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